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mitochondria, potential new therapeutic goals in pancreatic cancer - CRCM doctoral students Day 2021 will take place on May 28, La Cycline A2, Qui Maption L'HomГ©ostasy du CГґlon, EST UN-Favorites de pronostic Dans le Cancer ColorCtal -.
For more information, see the ED62 website from March 22,2021
Apply, send your CV and a letter of motivation to the PI of the subject
Deadline for submission: April
Our overall goal is to understand how the cells deal with this damaged DNA. We strive to understand the mechanisms that regulate the balance between error-free (damage prevention) and mutagenes (translation ion synthesis) -nna DNA damage tolerance mechanisms
Beginning of thesis 1 October, 2021
Application period 17. May 1721
The aim is to provide a therapeutic strategy aimed at the recognized stress mechanism in order to increase the effectiveness of the therapeutic treatments administered to patients.
Mastzell leukemia (ml) is a very aggressive blood cancer characterized by the excessive proliferation of immune cells, which are called mast cells (MC) in the bone marrow. The prognosis for patients with SCI is extremely arm (less than 6 months) and the resistance to cytoreductive therapies and tyrosine kinase inhibitors is common. The risk of development of SCI is higher in older topics, which generally have more fat tissue in the humpback mark of
as younger issues. Due to the potentially inflammatory nature of the bone marrow fatty tissue and its ability to act as fatty acids and adipocars, we want to study how the bone marrow would like to tissue leukemia mast cells and modulating diseases and resistance to standard therapies to develop better to better treatment options Developing SCI patients.
Our project combines molecular genetics and yeast domains, including a significant amount of bioinformatics analysis of NGS data and recombination profiles in which the laboratory has strong experience (Marsolier-Kergoat et al., 2018). Our goal is to better understand the balance between repair and rejection of the "heteroduplex" nna, which forms when two polymorphene molecules recombine each other. Such a balance controls both Meitic allelic mixtures, but also withotic and Meiotic non-allelic recombination, which lead to large chromosomal surroundings. This project is therefore of great interest in the areas of genom evolution and genomic instability, which are responsible for many human diseases, including cancers.
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