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Thesis suggestions - Greatest Essay Service - Affordable Essay (Dissertation) Writing Services

Disc proposals

mitochondria, potential new therapeutic goals in pancreatic cancer - CRCM doctoral students Day 2021 will take place on May 28, La Cycline A2, Qui Maption L'HomГ©ostasy du CГґlon, EST UN-Favorites de pronostic Dans le Cancer ColorCtal -

.

Recruiting future doctoral students in the context of the 2021 by the doctoral school of the life and health sciences (ED62) and the University of Aix-Marseille

For more information, see the ED62 website from March 22,2021

Apply, send your CV and a letter of motivation to the PI of the subject

Deadline for submission: April

DNA damage and genomine stability

Our overall goal is to understand how the cells deal with this damaged DNA. We strive to understand the mechanisms that regulate the balance between error-free (damage prevention) and mutagenes (translation ion synthesis) -nna DNA damage tolerance mechanisms

Beginning of thesis 1 October, 2021
Application period 17. May 1721

Spatio dynamic control that controls the survival of tumor cells

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The aim is to provide a therapeutic strategy aimed at the recognized stress mechanism in order to increase the effectiveness of the therapeutic treatments administered to patients.

Cadherins and pancreatic cancer aggregates

The aim of the proposed diploma thesis is to determine if the type of adhesive molecules, mainly Cadherins, in pancreatic ductaladenocinarian (PDAC), represents a signature of tumor aggressiveness. It aims to determine if these molecules influence migration, invasion and metastasis of tumor cells. Particular attention is paid to the ability of Cadherins to regulate the stability and activity of membrane microstructures called Invadopodia. These structures involved in the deterioration of the extracellular matrix are most likely involved in tumor metastases.

Effects of medullary adipocytes on progress and chemotion of myeloic leukemias

Mastzell leukemia (ml) is a very aggressive blood cancer characterized by the excessive proliferation of immune cells, which are called mast cells (MC) in the bone marrow. The prognosis for patients with SCI is extremely arm (less than 6 months) and the resistance to cytoreductive therapies and tyrosine kinase inhibitors is common. The risk of development of SCI is higher in older topics, which generally have more fat tissue in the humpback mark of
as younger issues. Due to the potentially inflammatory nature of the bone marrow fatty tissue and its ability to act as fatty acids and adipocars, we want to study how the bone marrow would like to tissue leukemia mast cells and modulating diseases and resistance to standard therapies to develop better to better treatment options Developing SCI patients.

Dynamic replication of telomer sequences

The goal of the project is to further investigate the molecular mechanisms that ensure the stability of repeated sequences in the yeast S. Pombe, focusing on the mechanism of fork stabilization and locking start. The main techniques used in the laboratory are: the genetics of yeast-s. Pombe, PCR, cloning, Western blot, Southern blot, co-immunicacitation (CoIP), chromatin immunoprecipitation (chip), two-dimensional DNA gel, yeast two hybrid, ....

Polymorphism and recombination

Our project combines molecular genetics and yeast domains, including a significant amount of bioinformatics analysis of NGS data and recombination profiles in which the laboratory has strong experience (Marsolier-Kergoat et al., 2018). Our goal is to better understand the balance between repair and rejection of the "heteroduplex" nna, which forms when two polymorphene molecules recombine each other. Such a balance controls both Meitic allelic mixtures, but also withotic and Meiotic non-allelic recombination, which lead to large chromosomal surroundings. This project is therefore of great interest in the areas of genom evolution and genomic instability, which are responsible for many human diseases, including cancers.

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